Correcting for targeted and control agent signal differences in paired-agent molecular imaging of cancer cell-surface receptors
نویسندگان
چکیده
منابع مشابه
A peptide-targeted MRI contrast agent for cancer molecular imaging
Introduction: Early detection and diagnosis of malignant tumors enable more efficacious cancer treatment at an earlier stage and improvement of cancer patients' survival and quality of the life. Magnetic resonance imaging (MRI) is a powerful imaging modality for cancer detection and diagnosis. However, current clinically used contrast enhanced MRI is not effective for molecular imaging because ...
متن کاملMultifunctional MIL-S─CUR@FC nanoparticles: a targeted theranostic agent for magnetic resonance imaging and tumor targeted delivery of curcumin
Introduction: Noninvasive magnetic resonance imaging (MRI) and targeted drug delivery systems, usually referred to as theranostic agents, are being developed to enable detection, site-specific treatment, and long-term monitoring. Materials and Methods: To elucidate the effects of coating on cellular uptake and biodistribution of n...
متن کاملMechanistic and quantitative insight into cell surface targeted molecular imaging agent design
Molecular imaging agent design involves simultaneously optimizing multiple probe properties. While several desired characteristics are straightforward, including high affinity and low non-specific background signal, in practice there are quantitative trade-offs between these properties. These include plasma clearance, where fast clearance lowers background signal but can reduce target uptake, a...
متن کاملaptamer-conjugated magnetic nanoparticles as targeted magnetic resonance imaging contrast agent for breast cancer
early detection of breast cancer is the most effective way to improve the survival rate in women. magnetic resonance imaging (mri) offers high spatial resolution and good anatomic details, and its lower sensitivity can be improved by using targeted molecular imaging. in this study, as1411 aptamer was conjugated to fe3o4@au nanoparticles for specific targeting of 4t1 cells that overexpress nucle...
متن کاملMR molecular imaging of prostate cancer with a small molecular CLT1 peptide targeted contrast agent.
Tumor extracellular matrix has abundance of cancer related proteins that can be used as biomarkers for cancer molecular imaging. In this work, we demonstrated effective MR cancer molecular imaging with a small molecular peptide targeted Gd-DOTA monoamide complex as a targeted MRI contrast agent specific to clotted plasma proteins in tumor stroma. We performed the experiment of evaluating the ef...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biomedical Optics
سال: 2018
ISSN: 1083-3668
DOI: 10.1117/1.jbo.23.6.066004